"Official medicines" is the best online drugstore.

World’s leading meds delivered to your door – and you don’t even need a prescription! Only certified, first class drugs on offer! Buy more and spend less with our great discount system.

The meds you need, reliable and hassle free! Top products of top brands.

The only pharmacy shop you will ever need! Approved drugs available without prescription. Best deals, unmatched service and shipping. 100% safe!

(koe-less-TIE-ruh-meen)
LoCHOLEST, LoCHOLEST Light, Prevalite, Questran, Questran Light
Class: Antihyperlipidemic/Bile acid sequestrant

 Action Increases removal of bile acids from body by forming insoluble complexes in intestine, which are then excreted in feces. As body loses bile acids, it converts cholesterol from blood to bile acid, thus lowering serum cholesterol.

 Indications Reduction of serum cholesterol in patients with primary hypercholesterolemia; relief of pruritus associated with partial biliary obstruction. Unlabeled use(s): Treatment of antibiotic-induced pseudomembranous colitis, bile salt-mediated diarrhea and digitalis toxicity.

 Contraindications Hypersensitivity to bile acid sequestering resins; complete biliary obstruction.

 Route/Dosage

ADULTS: PO 4 g 1 to 6 times/day; generally given 3 to 4 times/day.

 Interactions

Acetaminophen, amiodarone, corticosteroids, digitalis glycosides, HMG-CoA reductase inhibitors (eg, fluvastatin), methotrexate, some NSAIDs (eg, piroxicam), propranolol, thiazide diuretics, ursodiol, warfarin, and other drugs: Cholestyramine may interfere with the absorption of many drugs, especially those listed. Fats and fat-soluble vitamins A, D, E, and K: Cholestyramine may interfere with normal fat absorption and digestion; consider supplementation with these vitamins and with folic acid. Iopanoic acid: Coadministration may result in abnormal cholecystography.

 Lab Test Interferences Increased serum phosphorus and chloride; decreased serum sodium and potassium.

 Adverse Reactions

DERM: Rash; irritation of skin, tongue, and perianal area. GI: Constipation (can be severe and at times accompanied by fecal impaction); aggravation of hemorrhoids; abdominal pain and distention; bleeding; belching; flatulence; nausea; vomiting; diarrhea; heartburn; anorexia; steatorrhea. HEMA: Bleeding tendencies related to vitamin K deficiency; folic acid deficiency. META: Fat-soluble vitamin deficiencies; hyperchloremic acidosis and increased urinary calcium excretion; osteoporosis.

 Precautions

Pregnancy: Safety not established. Lactation: Undetermined. Children: Safety and efficacy not established. Carcinogenesis: Incidence of intestinal tumors in studies was greater in cholestyramine-treated rats than in controls; relevance to clinical practice is not known.

PATIENT CARE CONSIDERATIONS

 Administration/Storage

  • Administer cholestyramine separate from other drugs. Give other drugs 1 hr before or 4 to 6 hr after cholestyramine.
  • In general, give medication before meals.
  • Never administer dry powder without liquid. Use any noncarbonated fluid.
  • Instruct patient to chew tablets thoroughly. Follow with full glass of water.

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Document serum cholesterol and triglycerides levels.
  • Monitor electrolyte balance, and notify physician of increased serum phosphorus and chloride, or decreased serum sodium and potassium.
OVERDOSAGE: SIGNS & SYMPTOMS
  GI obstruction

 Patient/Family Education

  • In general, instruct patient to take medication before meals.
  • Advise patient to take any other medications, including otc medications, 1 hr before or 4 to 6 hr after taking cholestyramine.
  • Instruct patient to use dry powder form to mix with fluid (2 to 6 oz) according to packet directions.
  • Teach patient how to implement any vitamin and mineral supplementation recommended by the health care provider.
  • Help patient identify appropriate meal plans that supply adequate sodium and potassium and are low in phosphorus.
  • Tell patient to take prune juice, fruits and vegetables, and good fluid intake on a regular basis to avoid constipation. If constipation or other GI upset occurs, instruct patient to notify health care provider.
  • Advise patient to follow regular exercise routine.
  • Instruct patient to adhere to a diet low in fats and to participate in a weight management program, if appropriate.
  • Advise patients with phenylketonuria that a 5 g dose of Questran Light contains aspartame equivalent to 16.8 mg of phenylalanine.
  • Instruct patient to report the following symptoms to the health care provider: constipation, flatulence, nausea, heartburn, abnormal bleeding.

Popularity: 3% [?]


If you're still unable to find appropriate information in the article, please use search form below