(KLEM-ass-teen FEW-muh-rate)
Dayhist-1
Tablets
1.34 mg as fumarate (equiv. to 1 mg clemastine)
Tavist Allergy
Tablets
1.34 mg as fumarate (equiv. to 1 mg clemastine)
Clemastine Fumarate
Tablets
2.68 mg (equiv. to 2 mg clemastine)
Syrup
0.67 mg/5 mL (equiv. to 0.5 mg clemastine)
Tavist, Tavist-1  
Class: Antihistamine, Ethanolamine

 Action Competitively antagonizes histamine at H1 receptor sites.

 Indications Relief of symptoms associated with allergic rhinitis or other upper respiratiry allergies, such as sneezing, rhinorrhea, pruritus, and lacrimation; relief of mild, uncomplicated allergic skin manifestation of urticaria and angioedema.

 Contraindications Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO inhibitor therapy; use in newborn or premature infants and in nursing women.

 Route/Dosage

Adults and Children over 12 yr: PO 1.34 mg bid to 2.68 mg tid (max, 8.04 mg/day).

Children 6 to 12 yr: PO (syrup only) 0.67 to 1.34 mg bid (max, 4.02 mg/day).

 Interactions

Alcohol, CNS depressants: May cause additive CNS depressant effects.

MAO Inhibitors: May increase anticholinergic effects of clemastine fumarate.

 Lab Test Interferences

Skin testing procedures: Drug may prevent or diminish otherwise positive reaction to dermal reactivity indicators.

 Adverse Reactions

CARDIOVASCULAR: Orthostatic hypotension; palpitations; bradycardia; tachycardia; arrhythmias. CNS: Drowsiness (often transient); sedation; dizziness; faintness; disturbed coordination.EENT: Blurred vision; tinnitus. GI: Epigastric distress; nausea; vomiting; diarrhea; constipation. HEMATOLOGIC: Hemolytic anemia; thrombocytopenia; agranulocytosis. METABOLIC: Increased appetite; weight gain. RESPIRATORY: Thickening of bronchial secretions; chest tightness; wheezing; nasal stuffiness; dry mouth, nose and throat; sore throat; respiratory depression. OTHER: Hypersensitivity reactions; photosensitivity.

 Precautions

Pregnancy: Category B. Lactation: Contraindicated in nursing mothers. Children: Safety and efficacy in children less than 12 yr not established. Elderly: Elderly and debilitated patients are at an increased risk of dizziness, excessive sedation, syncope, toxic confusional states, and hypotension. Dosage reduction may be required. Special risk patients: Use drug with caution in patients predisposed to urinary retention, history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, or hypertension. Avoid use in patients with history of sleep apnea. Hepatic impairment: Use with caution in patients with cirrhosis or other liver disorders.

PATIENT CARE CONSIDERATIONS

 Administration/Storage

  • Administer drug whole. If patient cannot take whole tablet, administer syrup form.
  • Administer drug with food to avoid GI irritation.
  • Store at room temperature.

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies, especially to antihistamines.
  • Determine whether there is history of glaucoma, ulcer, asthma, or urinary tract obstruction.
  • Notify health care provider if patient has history of hypertension or other cardiovascular disorders or is taking an MAO inhibitor.
OVERDOSAGE: SIGNS & SYMPTOMS
  CNS depression, hallucinations, convulsions, cardiovascular collapse

 Patient/Family Education

  • Instruct patient not to take drug for 4 days before allergy testing.
  • Caution elderly patients that signs of CNS depression will be more pronounced.
  • Instruct patient to report the following symptoms to health care provider: difficulty breathing or problems voiding.
  • Advise patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
  • Instruct patient to avoid intake of alcoholic beverages or other CNS depressants.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
  • Caution patient to avoid exposure to sunlight and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.

Popularity: 3% [?]


If you're still unable to find appropriate information in the article, please use search form below