"Official medicines" is the best online drugstore.

World’s leading meds delivered to your door – and you don’t even need a prescription! Only certified, first class drugs on offer! Buy more and spend less with our great discount system.

The meds you need, reliable and hassle free! Top products of top brands.

The only pharmacy shop you will ever need! Approved drugs available without prescription. Best deals, unmatched service and shipping. 100% safe!

(sip-row-HEP-tuh-deen HIGH-droe-KLOR-ide)
Periactin
Tablets
4 mg
Syrup
2 mg/5 mL
PMS-Cyproheptadine
Class: Antihistamine

 Action Competitively antagonizes histamine at H1 receptor sites. Also exhibits antiserotonin activity.

 Indications Symptomatic relief of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis; amelioration of allergic reactions to blood or plasma; management of allergic pruritic symptoms, mild skin manifestations of uncomplicated urticaria and angioedema, and cold urticaria.

 Contraindications Hypersensitivity to antihistamines; newborn or premature infants; nursing mothers; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAO therapy.

 Route/Dosage

Adults: PO 4 mg q 8 hr then 4 to 20 mg/day; not to exceed 0.5 mg/kg/day.

Children: PO Total daily dosage 0.25 mg/kg or 8 mg/m2.

Children 7 to 14 yr: PO 4 mg bid or tid (max, 16 mg/day).

Children 2 to 6 yr: PO 2 mg bid or tid (max, 12 mg/day).

 Interactions

Alcohol, CNS depressants: May cause additive CNS depressant effects.

Fluoxetine: Effects of fluoxetine may be reversed.

MAOIs: Anticholinergic effects of cyproheptadine may increase.

 Lab Test Interferences In skin testing procedures, antihistamines may prevent or diminish otherwise positive reaction to dermal reactivity indicators.

 Adverse Reactions

CARDIOVASCULAR: Orthostatic hypotension; palpitations; tachycardia; reflex tachycardia; extrasystoles; faintness. CNS: Drowsiness (often transient); sedation; dizziness; faintness; disturbed coordination; confusion; restlessness; excitement; nervous tremor; paresthesias; convulsions; hallucinations. DERMATOLOGIC: Photosensitivity; rash. EENT: Dry mouth, nose, and throat; sore throat. GI: Epigastric distress; nausea; vomiting; diarrhea; anorexia; constipation; change in bowel habits. HEMATOLOGIC: Hemolytic anemia; thrombocytopenia; agranulocytosis. HEPATIC: Jaundice. RESPIRATORY: Thickening of bronchial secretions; chest tightness; wheezing; nasal stuffiness; respiratory depression.

 Precautions

Pregnancy: Category B. Lactation: Contraindicated in nursing women. Children: Safety and efficacy in children younger than 2 yr not established. Elderly: Dosage reduction may be required. Special risk patients: Use drug with caution in patients with predisposition to urinary retention, history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, or hypertension. Hepatic impairment: Use drug with caution in patients with cirrhosis or other liver disease. Respiratory disease: Generally not recommended for treatment of lower respiratory tract symptoms including asthma. Sedatives/CNS depressants: Avoid in patients with history of sleep apnea.

PATIENT CARE CONSIDERATIONS

 Administration/Storage

  • Administer medication with meals.
  • Scored tablets may be crushed.
  • Store in tightly closed container at room temperature.

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess baseline vital signs and lung sounds.
  • For diabetic patients, monitor blood glucose closely if taking sugar-based syrups.
  • Monitor weight weekly for significant increases.
  • Perform regular assessments and notify health care provider if patient exhibits signs of cardiovascular, neurologic, or respiratory dysfunction
    (eg, cardiac arrhythmia, hypotension, increased drowsiness or agitation, confusion, chest tightness, wheezing).
OVERDOSAGE: SIGNS & SYMPTOMS
  CNS depression, cardiovascular collapse, cardiovascular stimulation, seizures, hypotension, anticholinergic effects (eg, dilated pupils, dry mouth, flushing), hyperthermia (especially in children), dystonic reactions, dizziness, ataxia, blurred vision

 Patient/Family Education

  • Instruct diabetic patients to monitor blood glucose closely if taking syrup preparations.
  • Alert patients that syrup preparations contain alcohol, and advise against taking any additional alcoholic beverages or CNS depressants throughout therapy.
  • Explain potential effects of chronic dryness of oral tissues and encourage patient to maintain good oral hygiene and obtain regular dental care.
  • Explain that skin testing procedures may be affected if drug is not discontinued at least 4 days prior to test.
  • Tell patient to report any adverse reactions, including changes in urinary habits, to health care provider.
  • Instruct patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
  • Caution patients to avoid exposure to sunlight and prolonged exposure to extreme heat and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.
  • Instruct patient not to take OTC medications without consulting health care provider.

Popularity: 2% [?]


If you're still unable to find appropriate information in the article, please use search form below