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(dore-ZOLE-uh-mide)
Trusopt
Class: Carbonic anhydrase inhibitor

 Action Inhibits carbonic anhydrase enzyme, reducing rate of aqueous humor formation and thus lowering intraocular pressure (IOP).

 Indications Treatment of elevated IOP in patients with ocular hypertension or open-angle glaucoma.

 Contraindications Hypersensitivity to other sulfonamides.

 Route/Dosage

ADULTS: Ophthalmic One drop in affected eye(s) tid.

 Interactions

None well documented.

 Lab Test Interferences None well documented.

 Adverse Reactions

CNS: Headache. EENT: Ocular burning, stinging or discomfort; superficial punctate keratitis; blurred vision; tearing; conjunctivitis; ocular dryness; photophobia; ocular allergic reaction. OTHER: Nausea; bitter taste.

 Precautions

Pregnancy: Category C. Lactation: Unknown. Children: Safety and efficacy not established. Renal impairment: Not recommended for use in patients with severe renal impairment. Hepatic impairment: Use with caution. Contact lenses: Do not administer while wearing soft contact lenses; preservative may be absorbed by soft contact lenses. Concomitant use of oral carbonic anhydrase inhibitors: Not recommended. Bacterial keratitis: Can occur by using contaminated eye drops.

PATIENT CARE CONSIDERATIONS

 Administration/Storage

  • Wash hands before and after using.
  • To avoid contamination, do not touch tip of container to any surface or to eye structures.
  • Administer only to affected eye.
  • Gently apply pressure over nasolacrimal drainage system for 1 to 2 min after administration.
  • Replace cap after administration and keep tightly closed when not in use.
  • If used concomitantly with other topical ophthalmic drug products, wait 10 min between administering medications.
  • Do not use with soft contact lenses. They may absorb the preservative.
  • Other therapeutic interventions should be used in conjunction with dorzolamide in the treatment of acute narrow angle glaucoma.
  • Store at room temperature, protected from light.

 Assessment/Interventions

  • Obtain patient history.
  • Obtain baseline lab work including electrolytes and RBCs.
  • Note baseline intraocular pressure before starting medication.
OVERDOSAGE: SIGNS & SYMPTOMS
  Electrolyte imbalance, acidotic state, possible CNS effects

 Patient/Family Education

  • Instruct patient in proper administration of eye drop medications.
  • Instruct patient about the need to keep the tip of the dropper clean to prevent eye infections.
  • Inform patient that eye drops commonly produce transient stinging or discomfort upon administration, and to notify healthcare provider if they are severe.
  • Stress need to return to healthcare provider frequently for monitoring of eye pressure.
  • Inform patient not to wear soft contact lenses while using this medication.
  • Inform patient that they may experience a bitter taste in mouth immediately after administration.
  • Explain the need to be cautions when driving or participating in activities requiring close hand-eye coordination.
  • Instruct patient to notify the healthcare provider if any symptoms of eye infection (ie, burning, redness, itching, possible discharge) occur.

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