Components of these combinations include

Ergotamine tartrate: Ergotamine tartrate is used for its specific action against migraine.

Caffeine: Caffeine, a cranial vasoconstrictor, is added to ergotamine to enhance vasoconstrictive effects. It may enhance the absorption of ergotamine.

Barbiturates: Barbiturates are used for sedation.

Belladonna alkaloids: Belladonna alkaloids are used for their anticholinergic and antiemetic effects in individuals experiencing excessive nausea and vomiting during attacks.

Migraine Combinations
Trade Name Strength/Ingredient Average Dose
Cafergot Tablets, Ercaf Tablets, Wigraine Tablets 1 mg ergotamine tartrate, 100 mg caffeine 2 tablets at first sign of attack; follow with 1 tablet every ½ hour, if needed. Maximum dose is 6 tablets/attack. Do not exceed 10 tablets/wk.
Cafatine-PB Tablets 1 mg ergotamine tartrate, 100 mg caffeine, 0.125 mg 1- alkaloids of belladonna, 30 mg sodium pentobarbital 2 tablets at first sign of attack; follow with 1 tablet every ½ hour, if needed. Maximum dose is 6 tablets/attack. Do not exceed 10 tablets/wk.
Cafatine Suppository, Cafergot Suppository, Cafetrate Suppository 2 mg ergotamine tartrate, 100 mg caffeine Maximum dose is 2/attack.
Wigraine Suppository 2 mg ergotamine tartrate, 100 mg caffeine, 21.5 mg tartaric acid Maximum dose is 2/attack.

Combination Drugs

  1. Respiratory Combination Products
  2. Upper Respiratory Combinations
  3. Antibiotic Combinations
  4. Gastrointestinal Anticholinergic Combinations
  5. Narcotic Analgesic Combinations
  6. Nonnarcotic Analgesic Combinations
  7. Diuretic Combinations
  8. Migraine Combinations

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