Oseltamivir Phosphate
| (oh-sell-TAM-ih-veer) |
| Tamiflu |
| Class: Anti-infective/Antiviral |
Action Inhibition of influenza virus neuraminidase with possible alteration of virus particle aggregation and release.
Indications Treatment of uncomplicated acute illness caused by influenza infection in patients > 1 yr who have been symptomatic for £ 2 days; prophylaxis of influenza in patients ³ 13 yr.
Contraindications Standard considerations.
Route/DosageTreatment of Influenza
ADULTS AND ADOLESCENTS ³ 13 YR: PO 75 mg twice daily for 5 days. Renal impairment (Ccr 10 to 30 mL/min): PO 75 mg once daily for 5 days. ADULTS AND CHILDREN ³ 1 YR (who cannont swallow capsules): Suspension PO £ 15 kg (£ 33 lbs) administer 30 mg (2.5 mL) twice daily. > 15 to 23 kg (> 33 to 51 lbs) administer 45 mg (3.8 mL) twice daily. > 23 to 40 kg (51 to 88 lbs) administer 60 mg (5 mL) twice daily > 40 kg (> 88 lbs) administer 75 mg (6.2 mL) twice daily.
Influenza Prophylaxis
ADULTS AND ADOLESCENTS ³ 13 YR: PO 75 mg once daily for ³ 7 days. Renal impairment (Ccr 10 to 30 mL/min): PO 75 mg every other day.
Interactions None well documented.
Lab Test Interferences None well documented.
Adverse ReactionsRESP: Bronchitis. CNS: Insomnia; vertigo. GI: Nausea; vomiting.
PrecautionsPregnancy: Category C. Lactation: Undetermined. Children: Influenza treatment: Safety and efficacy not established in children < 1 yr. Influenza prophylaxis: Safety and efficacy not established in children < 13 yr. Repeated courses: Safety and efficacy not established. Renal impairment: Administer with caution.
| PATIENT CARE CONSIDERATIONS |
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Administration/Storage- Store at room temperature in a dry, closed container out of the reach of children.
- Administer within 2 days of the onset of symptoms.
- Administer with or without food.
- Food has increased tolerability for some patients.
Assessment/Interventions- Obtain patient history, including drug history and any known allergies.
- Monitor patient for potential hypersensitivity.
- Monitor for adverse events including nausea, vomiting, and diarrhea.
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Patient/Family Education- Instruct patient to begin treatment as soon as possible at the first appearance of flu symptoms.
- Instruct patient of the importance of nonpharmacological therapies such as adequate hydration and rest.
- Instruct patient to take oseltamivir as directed and to take any missed doses as soon as remembered unless it is within 2 hr before the next scheduled dose, and then continue to take oseltamivir at the usual scheduled times.
- Teach patient that oseltamivir is not a substitute for a flu vaccination, and to continue to receive an annual flu vaccination.
- Advise patient to notify physician immediately if pregnant, planning to become pregnant, or planning to breastfeed.
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