"Official medicines" is the best online drugstore.

World’s leading meds delivered to your door – and you don’t even need a prescription! Only certified, first class drugs on offer! Buy more and spend less with our great discount system.

The meds you need, reliable and hassle free! Top products of top brands.

The only pharmacy shop you will ever need! Approved drugs available without prescription. Best deals, unmatched service and shipping. 100% safe!


(fen-ox-ee-BEN-zuh-meen HIGH-droe-KLOR-ide)
Dibenzyline
Class: Antihypertensive/Agent for pheochromocytoma

 Action Irreversibly blocks alpha-adrenergic receptors.

 Indications Control of episodes of hypertension and sweating in patients with pheochromocytoma. Unlabeled use(s): Treatment of micturition disorders resulting from neurogenic bladder; treatment of functional outlet obstruction and partial prostatic obstruction.

 Contraindications Conditions in which fall in BP may be undesirable.

 Route/Dosage

ADULTS: PO 10 mg bid initially. Usual dosage range is 20 to 40 mg bid to tid. CHILDREN: PO 1 to 2 mg/kg/day in 3 to 4 divided doses.

 Interactions

Epinephrine: Exaggerated hypotensive response and tachycardia may occur when epinephrine, or other agents that stimulate both alpha- and beta-receptors, are given concomitantly with phenoxybenzamine.

 Lab Test Interferences None well documented.

 Adverse Reactions

CV: Orthostatic hypotension; tachycardia. CNS: Drowsiness; fatigue. EENT: Miosis. GI: Gastrointestinal irritation. GU: Inhibition of ejaculation. RESP: Nasal congestion.

 Precautions

Pregnancy: Safety not established. Lactation: Undetermined. Special-risk patients: Administer drug with caution to patients with marked cerebral or coronary arteriosclerosis or renal damage. Adrenergic blocking effects may aggravate respiratory infections.

PATIENT CARE CONSIDERATIONS

 Administration/Storage

  • Give drug with milk or in divided doses to reduce GI irritation.
  • Store in airtight container and protect from light.

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Instruct patient to change position slowly, especially from lying to sitting up or standing, and to dangle and move legs before standing.
  • Assess for the following adverse reactions: Orthostatic hypotension, tachycardia, nasal congestion.
  • Assess for effectiveness (lowering of BP) periodically.
  • Take safety precautions if patient develops lightheadedness.
  • If shocklike state develops, place patient in Trendelenburg position. Notify physician and begin emergency interventions.
  • During dosage adjustments, monitor BP and pulse (eg, quality, rate, rhythm) with patient in lying and standing position for 4 days.
  • In patients with peripheral vasospastic problems, observe for improvement in skin color, temperature, and quality of peripheral pulses.
OVERDOSAGE: SIGNS & SYMPTOMS
  Orthostatic hypotension, dizziness, fainting, tachycardia, vomiting, lethargy, shock

 Patient/Family Education

  • Advise patient to avoid alcoholic beverages.
  • Stress to patient importance of weight reduction, sodium and alcohol restriction, discontinuation of smoking, regular exercise, and behavior modification.
  • Instruct patient to avoid otc cough, cold, or allergy medications containing sympathomimetics without consulting physician.
  • Instruct patient to avoid sudden position changes to prevent orthostatic hypotension. Warn patient that taking a hot bath or shower may aggravate dizziness.
  • Inform patient that drug may cause nasal congestion and constricted pupils.
  • Advise patient that inhibition of ejaculation may occur, but reassure patient that this condition generally decreases with continued therapy.
  • Advise patient that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.

Popularity: 1% [?]


If you're still unable to find appropriate information in the article, please use search form below